Calcitonin Gene-Related Peptide (CGRP)

CGRP is a neuropeptide widely distributed in the nervous system, where it is thought to play a role in several processes, including vasodilation of cerebral and dural vessels, release of inflammatory mediators and transmission of nociceptive signals to the central nervous system.5,6

The video below offers a more in-depth look at migraine pathophysiology
and the role of CGRP.

Several lines of evidence support the role of CGRP in migraine. Specifically:7,8

  • In the absence of triggers or during treatment, it has been noted that migraine patients' CGRP levels remain lower.
  • Elevations in serum and salivary CGRP have been observed in both spontaneous migraine attack and nitric oxide-induced attack.
  • Intravenous CGRP can induce a migraine attack in a matter of hours in migraine patients. This was not observed in people who do not suffer from migraine.

Researchers continue to study the role of selective CGRP receptor antagonists (ligands) in migraine and other systems.9

Go to Considerations for Migraine Prevention